RECURRENT C. DIFF IS A SERIOUS CONDITION THAT AFFLICTS A SIGNIFICANT NUMBER OF PATIENTS

C. diff has been characterized as an Urgent Health Threat by the Centers for Disease Control and Prevention (CDC)1

The symptoms of recurrent C. diff include watery diarrhea with up to 15 bowel movements a day, which significantly impacts a patient's quality of life2

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My family and friends have become used to me canceling plans

Quotes are from patients with recurrent C. diff (or their caregivers)

  • *196 of 413 patients were hospitalized within 6 weeks of completing their index C. diff antibiotic treatment or date of index hospitalization discharge, whichever occurred later.
  • †On average, approximately 2 of the 9 days were attributable to the recurrent C. diff episode.
  • ‡As measured at 6 months after their initial C. diff episode.

RECURRENT C. diff CAN SIGNIFICANTLY IMPACT A PATIENT'S QUALITY OF LIFE AND PSYCHOLOGICAL HEALTH

Recurrent C. Diff Work

Recurrent C. diff can jeopardize patients' professional lives due to missed work and decreased productivity

>75% of actively employed patients stopped work either during or after recurrent C. difficile infection and treatment§

Recurrent C. Diff Mental Health

Patients with recurrent C. diff report harmful psychological consequences, including fear and worsening anxiety/depression

Due to the uncertainty of having another recurrence, these psychological consequences can persist, as demonstrated by ~75% of patients who reported experiencing them over a year later

  • §An observational cross-sectional study involving 350 participants with self-reported C. diff (n=115 with current C. diff; n=235 with past C. diff) completed an online survey to qualitatively assess Health-Related Quality of Life.

Learn about the role of the microbiome, and take the C. DIFF CHALLENGE quiz

EXPLORE THE ROLE
OF THE MICROBIOME

References: 1. CDC. Atlanta, GA: U.S. Department of Health and Human Services, 2019. doi: http://dx.doi.org/10.15620/cdc:82532. 2. Cole SA, Stahl TJ. Clin Colon Rectal Surg. 2015;28(2):65-69. doi:10.1055/s-0035-1547333. 3. Desai K, Gupta SB, Dubberke ER, Prabhu VS, Browne C, Mast TC. BMC Infect Dis. 2016;16(303):1-10. doi:10.1186/s12879-016-1610-3. 4. Kelly CP. Clin Microbiol Infect. 2012;18(suppl 6):21-27. doi:10.1111/1469-0691.12046. 5. McFarland LV, Elmer GW, Surawicz CM. Am J Gastroenterol. 2002;97(7):1769-1775. doi:10.1111/j.1572-0241.2002.05839.x. 6. McFarland LV, Surawicz CM, Greenberg RN, et al. JAMA. 1994;271(24):1913-1918. 7. Olsen MA, Yan Y, Reske KA, Zilberberg M, Dubberke ER. Am J Infect Control. 2015;43(4):318-322. doi:10.1016/j.ajic.2014.12.020. 8. Zhang D, Prabhu VS, Marcella SW. Clin Infect Dis. 2018;66(9):1326-1332. doi:10.1093/cid/cix1021. 9. Olsen MA, Yan Y, Reske KA, Zilberberg MD, Dubberke ER. Clin Microbiol Infect. 2015;21(2):164-170. doi:10.1016/j.cmi.2014.08.017. 10. Lurienne L, Bandinelli PA, Galvain T, Coursel CA, Oneto C, Feuerstadt P. J Patient Rep Outcomes. 2020;4(1):14. doi:10.1186/s41687-020-0179-1.