RECURRENT C. diff AFFLICTS A SIGNIFICANT NUMBER OF PATIENTS

There are approximately 170,000 episodes of recurrent C. diff (one or more recurrences) in the US every year

C. diff infections are caused by Clostridioides difficile, a spore-forming, gram-positive anaerobic bacillus that causes severe diarrhea and colitis

>40%

After the first C. diff recurrence, a patient's risk of subsequent recurrences increases to >40%11

~50%

Approximately half of all patients with recurrences have a C. diff-related hospital readmission12*

  • *196 of 413 patients were hospitalized within 6 weeks of completing their index C. diff antibiotic treatment or date of index hospitalization discharge, whichever occurred later.
SEE THE IMPACT

THE FIRST C. diff RECURRENCE CAN SIGNAL A DISRUPTED MICROBIOME

Disrupted Microbiome Disrupted Microbiome Disrupted Microbiome Disrupted Microbiome

While antibiotics are effective in treating C. diff, they inherently do not protect against recurrence

Microbiome restoration helps prevent C. diff spore germination1-8

Learn about the role of the microbiome, and take the C. DIFF CHALLENGE quiz

EXPLORE THE ROLE
OF THE MICROBIOME

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12. Olsen MA, Yan Y, Reske KA, Zilberberg M, Dubberke ER. Am J Infect Control. 2015;43(4):318-322. doi:10.1016/j.ajic.2014.12.020. 13. Oksi J, Anttila VJ, Mattila E. Ann Med. 2020;52(1-2):12-20. doi:10.1080/07853890.2019.1701703 14. Budi N, Safdar N, Rose WE. FEMS Microbes. 2020;1(1):1-8. doi:10.1093/femsmc/xtaa001. 15. Lewis BB, Buffie CG, Carter RA, et al. J Infect Dis. 2015;212(10):1656-1665. doi:10.1093/infdis/jiv256. 16. Chang JY, Antonopoulos DA, Kalra A, et al. J Infect Dis. 2008;197(3):435-438. doi:10.1086/525047.